Zach Morris, MD, PhD
Using radiation to stimulate the immune system in cancer treatment.
Using in vivo in syngeneic murine tumor models as well as ex vivo functional immune analyses, Dr. Morris will use this award to conduct pilot studies exploring the capacity of radiation therapy to enhance the anti-tumor response elicited by selected immunotherapies. Specifically, he will test whether a cooperative interaction is observed between radiation and tumor-specific antibody in novel murine models of huHER-2+ breast and huEGFR+ head and neck cancers. Dr. Morris will also test whether in situ vaccine may be elicited by the combination of radiation and intratumor injection of novel immunotherapies targeting ICOS, OX40, CD73, and TLR ⅞.